Single-cell analysis of Crohn's disease reveals a detailed picture of inflammation in the gut

Researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have constructed a high-resolution cellular map of Crohn
Researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have constructed a high-resolution cellular map of Crohn's disease, a chronic condition in which a hyperactive immune system causes inflammation throughout the gut, leading to symptoms including abdominal pain, diarrhea, and weight loss. The disease is difficult to treat and often requires hospitalization.

Mapping the second brain: Single cell characterization of the enteric nervous system reveals clues to IBD - 10x Genomics

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Immune responses in chronic inflammatory bowel diseases - New population of immune cells that is highly abundant in Crohn's disease patients

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Ramnik Xavier named as a core member of Broad Institute

Pro-inflammatory innate-like T cells are expanded in the blood and inflamed intestine in Crohn's Disease

Inflammatory Bowel Disease (IBD) - Life Extension

Xavier lab Broad Institute

A detailed atlas of the developing brain

Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn's Disease - ScienceDirect

Single-cell analysis of Crohn's disease reveals a detailed picture

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Medical Xpress Archive : 31/01/2023( continued page 10)

Frontiers Identification of a Disease-Associated Network of Intestinal Immune Cells in Treatment-Naive Inflammatory Bowel Disease