Drug-Like Molecules Regenerate Hair Cell-Like Cells in Adult Mice

“Think about a brake when driving a car,” Chen explains. “If the brake is always engaged, you can’t drive. We found an siRNA that could remove the brake in this genetic pathway.”

Hearing Health Foundation (HHF) is the largest non-profit funder of hearing research. Since 1958, HHF has given away millions of dollars to hearing and balance research, including work that led to cochlear implant technology and now through the Hearing Restoration Project is working on a cure for hearing loss and tinnitus. HHF also publishes Hearing Health magazine, a free consumer resource on hearing loss and related technology, research, and products.

Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

Maintaining the equilibrium: inner ear hair cell regeneration

Transcriptomic characterization of dying hair cells in the avian cochlea - ScienceDirect

Cells, Free Full-Text

Highlights From the Hearing Restoration Project — Hearing Health

Drug-Like Cocktail Used by Researchers to Regenerate Hair Cells for Hearing Loss in Preclinical Study

Frontiers TUB and ZNF532 Promote the Atoh1-Mediated Hair Cell Regeneration in Mouse Cochleae

Hearing Loss Treatment Report

Cells, Free Full-Text

Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

IJMS, Free Full-Text

IJMS, Free Full-Text

Frontiers Characterization of Hair Cell-Like Cells Converted From Supporting Cells After Notch Inhibition in Cultures of the Organ of Corti From Neonatal Gerbils

Brain Connectivity Patterns in Children With Autism Spectrum

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals