Yunlong Richard Cao on X: It's critical to test how these RBD hotspots could combine to achieve max immune evasion without losing affinity to ACE2. After careful consideration, besides the emerging K478R/F456L

Yunlong Richard Cao on X: Sharing some new experimental data on BA.2.86: 1) BA.2.86 is antigenically distinct compared to XBB.1.5. 2) BA.2.86 can significantly escape XBB-infection/vaccination induced antibodies. 3) However, the infectivity

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

Frontiers The XBB.1.5 slightly increase the binding affinity for host receptor ACE2 and exhibit strongest immune escaping features: molecular modeling and free energy calculation

The Potential for SARS-CoV-2 to Evade Both Natural and Vaccine-induced Immunity

Yunlong Cao Lab Peking University

Yunlong Richard Cao on X: It's critical to test how these RBD hotspots could combine to achieve max immune evasion without losing affinity to ACE2. After careful consideration, besides the emerging K478R/F456L

Yunlong Cao Lab Peking University

The Potential for SARS-CoV-2 to Evade Both Natural and Vaccine-induced Immunity

Frontiers COVID-19—A Theory of Autoimmunity Against ACE-2 Explained

Passive Immunotherapy Against SARS-CoV-2: From Plasma-Based Therapy to Single Potent Antibodies in the Race to Stay Ahead of the Variants

Viruses, Free Full-Text

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution